Chemoenzymatic Preparation of Nucleoside Triphosphates
نویسندگان
چکیده
منابع مشابه
Enzymatic synthesis of nucleoside diphosphates and triphosphates.
It has been recognized from recent studies that nucleoside triphosphates, other than ATP,’ function in biologic systems as phosphorylating agents (1) and in coenzyme synthesis (2) in a manner analogous to that of ATP. The discovery of the natural occurrence of a variety of purine and pyrimidine nucleoside diand triphosphates (3-5) and the likelihood that new biologic functions for these nucleot...
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The traditional strategy for the introduction of chemical functionalities is the use of solid-phase synthesis by appending suitably modified phosphoramidite precursors to the nascent chain. However, the conditions used during the synthesis and the restriction to rather short sequences hamper the applicability of this methodology. On the other hand, modified nucleoside triphosphates are activate...
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During the last quarter of the century almost no other aspect of organic synthesis has received as much attention as the preparation of enantiomerically pure compounds. The synthesis of optically active materials is an important task and represents a challenge to synthetic organic chemists. Increasing interest in the understanding of biological processes and the general recognition that chirali...
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ژورنال
عنوان ژورنال: Current Protocols in Nucleic Acid Chemistry
سال: 2004
ISSN: 1934-9270,1934-9289
DOI: 10.1002/0471142700.nc1302s16